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Melanin is the natural chromophore for targeting hairfollicles in the visible to near-infrared region, Lasers or lightsources that operate in the red or near-infrared wavelength region liein an optical window of the spectrum in which selective absorption bymelanin is combined with deep penetration into the dermis. Therefore,deep and selective heating of the hair shaft, the hair follicleepithelium, and the heavily pigmented matrix is possible in the 600nmto 1100nm region. However, melanin in the epidermis presents acompeting site for absorption. Selective cooling of the epidermis hasbeen shown to minimize epidermal injury.Photomechanicaldestruction of hair has been attempted with very short nanosecondpulses. It has been done by the help of Q-switched 1064-nm Nd:YAGlasers, with and without carbon suspension. Short pulses are used totarget hair follicles resulting in rapid heating of the chromophore(melanin). It leads to photo acoustic shock waves that cause focalphotomechanical disruption of the melanocytes but not completefollicular disruption.Many people want to ask their most important question: When will my hair grow back The answer to this common question is that hair should begin regrowing in about ten months. This will be a very important and happy time for the individual who has come through cancer treatment. Throughout this time and until the hair is fully grown back in, the wigs and other head coverings may continue to be used.